Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: Though periventricular gradient (PVG) mapping has been demonstrated to be useful, previous studies have employed 2D magnetization transfer ratios and T1 maps, which are not specific to myelin.
Goal(s): This study investigates the use of synthetic MRI myelin maps to assess the periventricular gradient (PVG) of myelin volume fraction (MVF) in multiple sclerosis (MS) patients.
Approach: This study includes 22 healthy individuals, 84 patients with relapsing-remitting MS (RRMS), and 17 patients with secondary progressive MS (SPMS).
Results: PVGs of RRMS and SPMS were higher than that of healthy individuals, with SPMS showing higher PVG than RRMS.
Impact: In conclusion, the influence of demyelination in MS appears to be more prominent in the vicinity of the ventricles.
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