Abstract #3004

Spatial characterization of signal-to-noise ratio (SNR) differences among multiple sites using a phantom

Jasmin Merhout¹, Enedino Hernández-Torres¹, Vanessa Wiggermann¹, Finn Sellebjerg^2,3, Jeppe Christensen⁴, Karam Sidaros¹, Hartwig Siebner^1,5, and Henrik Lundell^1,6

¹Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, DRCMR, Copenhagen, Denmark, ²Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital-Rigshospitalet, Glostrup, Copenhagen, Denmark, ³Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ⁴Department of Neurology, Danish Multiple Sclerosis Center , Copenhagen University Hospital-Rigshospitalet, Glostrup, Copenhagen, Denmark, ⁵Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Copenhagen, Denmark, ⁶Department of Health Technology, Technical University of Denmark, Lyngby, Lyngby, Denmark

Synopsis

Keywords: Data Processing, Phantoms

Motivation: The motivation came to acknowledge the aid for sequence standardization and to assess other site-related differences.

Goal(s): We aim to consider the SNR differences to improve comparability between sites in structural analysis of brain data.

Approach: We describe preliminary MRI phantom data from a longitudinal, multi-site MS study, illustrating an approach to sequence standardization and assessing site-related differences.

Results: Scan-rescan data were collected on three 3T MRI systems, using study specific, previously optimized sequences. Signal-to-noise ratio (SNR) was measured on a 16 x 16 grid structure within the phantom. Imaging voxels within the grid where algorithmically identified and SNR assessed in each cube.

Impact: Large between-site differences in SNR and spatial variability were observed, while longitudinal data showed good consistency in mean SNR and spatial appearance. These differences underscore the need for correction to improve between-site comparability.

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