Abstract #3014

Quality assurance of quantitative MRI protocol for a hypoxia imaging clinical study in glioblastoma

Yu-Feng Wang^1,2, James Drummond^3,4,5, Marco Mueller⁶, Paul J. Keall¹, Kieran O'Brien⁶, Jeremy Booth^2,3, Jackie Yim^3,4,7, Jonathon Parkinson^4,8, Shona Silvester¹, Dale L. Bailey⁹, Michael Back^3,4, Heidi Luton¹⁰, David Waddington¹, and Caterina Brighi¹

¹Image X Institute, Sydney School of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia, ²Institute of Medical Physics, School of Physics, The University of Sydney, Sydney, New South Wales, Australia, ³Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Sydney, New South Wales, Australia, ⁴The Brain Cancer Group Sydney, St Leonards, New South Wales, Australia, ⁵Department of Neuroradiology, Royal North Shore Hospital, Sydney, New South Wales, Australia, ⁶Siemens Healthcare Pty Ltd, Brisbane, Queensland, Australia, ⁷Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, New South Wales, Australia, ⁸Department of Neurosurgery, Royal North Shore Hospital, Sydney, New South Wales, Australia, ⁹Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia, ¹⁰Department of Neuroradiology, North Shore Radiology and Nuclear Medicine, St Leonards, New South Wales, Australia

Synopsis

Keywords: System Imperfections, Precision & Accuracy, Phantoms, brain, quantitative imaging, system imperfections: Measurement & correction

Motivation: A quantitative MRI (qMRI) protocol was developed for a clinical study aimed at identifying regions of tumour hypoxia in glioblastoma patients. Technical validation of qMRI biomarkers requires thorough testing of the protocol against reference standards.

Goal(s): To assess and report accuracy, repeatability, and reproducibility of the qMRI protocol.

Approach: Test-retest scans of the NIST systems phantom were acquired on two 3T MAGNETOM VIDA scanners. Accuracy, repeatability and reproducibility of T1, T2 maps, and calibrated T1 maps from dynamic oxygen enhanced imaging were assessed.

Results: qMRI parameters acquired with the study protocol showed accuracy, repeatability and reproducibility comparable to published literature findings.

Impact: Accuracy and precision (repeatability and reproducibility) of a qMRI protocol for glioblastoma hypoxia imaging were quantified. T1, including calibrated dynamic values, showed high accuracy and precision. T2 showed low accuracy compared to published findings. T2 and T2* showed moderate precision.

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