Keywords: Non-Proton, Non-Proton, Spectroscopy, carbon-13
Motivation: To develop a safe MR method to non-invasively measure skeletal muscle glycogen levels in humans.
Goal(s): To reduce SAR without degrading the spectral quality of the 1H-decoupled C1-glycogen peak in 13C MRS.
Approach: To introduce the two-pulse phase-modulated (TPPM) 1H decoupling scheme, which is widely used for 13C NMR of organic solids, into the 13C MRS pulse sequence for a clinical scanner.
Results: The 1H-decoupled C1-glycogen peak could be obtained from a solution phantom using a clinical 3T scanner while reducing SAR with shortening the duration of the TPPM 1H decoupling during 13C FID acquisition.
Impact: 13C MRS with the TPPM 1H decoupling for measuring human skeletal muscle glycogen levels may be more advantageous at high magnetic fields due to the lower SAR, leading to higher SNR or shorter scan times.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords