Meeting Banner
Abstract #3031

Improved spatial resolution for in vivo deuterium metabolic imaging using 2H 3D-FID-MRSI with concentric ring trajectories.

Fabian Niess1, Bernhard Strasser1, Lukas Hingerl1, Viola Bader1, Sabina Frese1, William T Clarke2, Stanislav Motyka1,3, Eva Niess1,3, Martin Krssak4, Siegfried Trattnig1,5, Thomas Scherer4, Rupert Lanzenberger6, and Wolfgang Bogner1,3
1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Wellcome Centre for Integrative Neuroimaging, FMRIB,Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, 4Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 5Institute for Clinical Molecular MRI, Karl Landsteiner Society, Vienna, Austria, 6Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Deuterium, Deuterium, Deuterium Metabolic Imaging, 7T, human brain, Magnetic Resonance Spectroscopic Imaging

Motivation: Sufficiently high spatial resolution for metabolic mapping of brain glucose metabolism is crucial as regional differences are present in many severe brain diseases, such as dementia, tumors and schizophrenia.

Goal(s): To increase spatial resolution for whole brain deuterium metabolic imaging without prolonging scan times.

Approach: Implement density-weighted concentric ring trajectory for 2H FID-MRSI readout to achieve 2.5-fold increase in spatial resolution while maintaining sufficient SNR.

Results: Contrast-enhanced metabolic maps were acquired using CRT with significantly higher (+33%,p<0.01) Glx concentrations in GM regions compared to WM, while no differences were observed using lower resolution phase-encoded MRSI.

Impact: Increased spatial resolution for dynamic deuterium metabolic imaging is crucially needed as many severe brain pathologies feature regional differences in brain glucose metabolism. However, prolonged scan times ultimately limit the achievable spatial resolution using conventional methods for whole brain DMI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords