Keywords: Non-Proton, Metabolism, Migraine, 31P Spectroscopy, Preclinical, Central Sensitization, Ultra-high field
Motivation: Migraine is a disorder of neuronal hyperexcitability, but previous work has not been able to capture energetic processes non-invasively during active central sensitization, only after or between migraine attacks.
Goal(s): This preclinical study evaluates whole brain energetic metabolism and remodeling during a nitroglycerin-induced migraine attack.
Approach: 31P spectroscopy using ISIS was used to measure phosphocreatine and ATP levels at baseline and then over a 3-hour period post-NTG administration.
Results: Most notable is the increase in phosphocreatine compared to baseline and controls, as well as an increase in ATP compared to baseline. Both indicate energetic remodeling during central sensitization prior to migraine pain onset.
Impact: Increased phosphocreatine and ATP over the entire brain demonstate significant energetic fluxes during cerebral central sensitization and prior to nociception. This energetic remodeling informs understanding of fundamental migraine pathophysiology and its timing, potentially impacting the administration of potential clinical interventions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords