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Abstract #3046

Longitudinal Study of the Tissue Sodium Concentration in the Human Liver via Quantitative 23Na MRI at 7T

Jana Losch1,2, Armin M. Nagel1,3, Anna K. Scheipers1,2, Mark E. Ladd1,2,4, and Tanja Platt1
1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Synopsis

Keywords: Non-Proton, Liver, X-Nuclei, 23Na MRI, Sodium, Ultrahigh Field, 7T, Tissue sodium concentration

Motivation: A scarcity in literature values for the tissue sodium concentration (TSC) in the healthy liver complicates the evaluation of the TSC in the diseased liver.

Goal(s): This study aimed to establish TSC levels in one healthy liver on multiple days to explore potential concentration variations.

Approach: The TSC was assessed using B1 field corrected and respiratory-sorted quantitative 23Na MRI.

Results: The TSC values obtained in the healthy liver remained stable over a week and aligned with existing literature values.

Impact: The study's finding of a consistent tissue sodium concentration (TSC) over time in one healthy liver is a valuable insight. It indicates that changes in liver TSC might be accurately linked to diseases, which could improve diagnosis of liver diseases.

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