Abstract #3053

Detecting glucose metabolism abnormality in Six-Month-Old AD mice using deuterium magnetic resonance imaging

Ganghan Yang^1,2, Qian Wan¹, Hao Peng¹, Yang ZHou¹, Junyi Duan^1,2, Jiaxu Li¹, Shiyi Zhang^1,2, Enhua Xiao^1,2, Xin Liu¹, Ye Li¹, and Chao Zou¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²College of Engineering, Southern University of Science and Technology, Shenzhen, China

Synopsis

Keywords: Deuterium, Deuterium, Alzheimer's Disase

Motivation: Impaired brain energy metabolism at early stage is found to be the driving factor of Alzheimer’s Disease (AD) progression.

Goal(s): The study aim to investigate the potential of using deuterium magnetic resonance imaging to characterize the glucose metabolism in AD mouse model.

Approach: Deuterium magnetic resonance spectroscopic imaging with the administration of [2,3,4,6,6’-²H₅]-D-Glucose in 5xFAD and C57 mice.

Results: Our preliminary results indicate higher glutamine/glutamate (Glx) production rate in 5xFAD mice compared to normal mice, especially in the hypothalamus region.

Impact: Our work may shed light on developing new method in the early detection of AD based on the glucose metabolism abnormality.

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