Keywords: Hyperpolarized MR (Non-Gas), Alzheimer's Disease, metabolism, hyperpolarized 13C
Motivation: The accelerating prevalence of Alzheimer's disease (AD) around the world urges the need not only for more effective treatment but also for improved non-invasive monitoring of onset and progression.
Goal(s): Our goal is to investigate if the clinically expanding HP 13C MR method could improve diagnosis and monitoring of AD.
Approach: hAPP-J20 AD mice and age-/sex-matched wild-type were imaged using HP 13C MR at 2-months-old (presymptomatic) and 14-months-old (amyloid plaques accumulation). The impact of sex, genotype, age, and their interactions, on the derived HP metrics was investigated.
Results: HP13C metabolic imaging can provide crucial information on sexual dimorphism and metabolic aging in AD.
Impact: Hyperpolarized 13C imaging provides unique metabolic information specific to sex and APP mutational status in an AD model. Upon clinical translation, such method could improve early diagnosis and patient-centric monitoring of AD progression, and potentially assessment of therapeutic response.
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