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Abstract #3068

Comparison of Hyperpolarized 13C Pyruvate MRI and 1H MRI for Predicting Renal Tumor Aggressiveness

Xiaoxi Liu1, Shuyu Tang2, Allison Sabb3, Di Cui1, Adam Olshen4, Jeremy W. Gordon1, Maxwell V. Meng5, Peder E.Z. Larson1,6, and Zhen J. Wang1
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Vista.ai Inc., Los Altos, CA, United States, 3Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States, 4Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States, 5Department of Urology, University of California San Francisco, San Francisco, CA, United States, 6Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Cancer

Motivation: Current imaging methods have limitations in predicting localized renal tumor aggressiveness.

Goal(s): Comparing the performance of predicting high grade ccRCCs, typically considering as aggressive RCCs, by different MR imaging methods.

Approach: We compared the performance of hyperpolarized 13C pyruvate MRI and 1H MRI for predicting high-grade ccRCCs in 22 localized renal tumors.

Results: Hyperpolarized 13C-labelled lactate-to-pyruvate ratio was significantly higher in high-grade ccRCCs compared to other renal tumor group(benign renal tumors, chromophobe RCCs, and low grade ccRCCs, P=0.003). Neither the percentage signal intensity change from contrast-enhanced MRI nor the apparent diffusion coefficient from diffusion-weighted MRI was able to differentiate between the two groups.

Impact: Compared to 1H MRI, HP 13C MRI enables improved prediction of high-grade clear cell renal cell carcinomas.

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Abstract

Keywords