Keywords: Epilepsy, Brain Connectivity, Spasms, Infantile; Magnetic Resonance Imaging; Imaging; Three-Dimensional; Cerebral Cortex
Motivation: Whether there is micro-structural alteration in the temporal lobe of Infantile epileptic spasms syndrome (IESS) patients is yet to be clarified, of which resulting in severe language function impairment.
Goal(s): To explore the potential mechanism of neurological impairment in children with IESS.
Approach: We conducted a study with BSID-II for clinical evaluation, meanwhile voxel-based morphometry (VBM) for MRI data analysis.
Results: In IESS group, the most significant volume loss of gray matter in right fusiform (Broadman area 21) and middle temporal gyrus (Wernicke's area) were key node for voice recognition, language processing, semantic retrieval, memory, and understanding network.
Impact: The findings of this study light up an anatomical basis for language impairment in children with IESS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords