Abstract #3086

Brain atrophy in epilepsy, a function of etiology? A preliminary analysis

Stefanie Chambers^1,2, Leo Hofer³, Philipp Lazen^1,2, Matthias Tomschik¹, Christoph Baumgartner⁴, Johannes Koren⁴, Wolfgang Bogner^2,5, Christian Dorfer¹, Florian Mayer⁶, Katharina Moser⁶, Martha Feucht⁶, Ekatarina Pataraia⁷, Giuseppe Pontillo⁸, Siegfried Trattnig^2,5, Gregor Kasprian³, Karl Rössler¹, Gilbert Hangel^1,2, and Lukas Haider^3,8

¹Department for Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria, ⁴Department for Neurology, Medical Hospital Hietzing, Vienna, Austria, ⁵Christian Doppler Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria, ⁶Center of rare and complex epilepsies, member of ERN EpiCARE, Department of Paediatrics, Medical University Vienna, Vienna, Austria, ⁷Department for Neurology, Medical University of Vienna, Vienna, Austria, ⁸NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: Epilepsy, Gray Matter

Motivation: The relationship of grey-matter atrophy in structural epilepsy across various etiologies remains poorly understood.

Goal(s): To perform volumetric brain MRI analysis in the presence of structural epileptogenic brain lesions.

Approach: 68 subjects with structural epilepsy were longitudinally imaged, grey-matter volume estimates were derived from SynthSeg segmentations and corrected for structural lesions with manual segmentation. Grey-matter volume change was assessed over five structural etiological groups and related to the Seizure Frequency Score.

Results: Our data show significant correlation between grey-matter volume loss and the Seizure Frequency Score. We could find no clear trend across etiological groups in our primary analysis.

Impact: Our analysis of grey-matter volume loss in structural epilepsy shows a correlation with the Seizure Frequency Score, supporting the concept of epilepsy-associated neurodegeneration and highlighting the importance of early diagnosis and treatment.

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