Abstract #3096

Textural changes in the amygdala are more sensitive than volumetric changes in cocaine use disorder patients undergoing therapy

Shounak Nandi^1,2, Pavan Poojar¹, Keren Bachi³, Shilpa Taufique³, Yasmin Hurd³, and Sairam Geethanath¹

¹Accessible MR Lab, Biomedical Engineeing and Imaging Institute, Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York City, NY, United States, ²Munich Institute of Biomedical Engineering, Technical University of Munich, Munich, Germany, ³Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, United States

Synopsis

Keywords: Data Processing, Data Processing, Texture analysis, Cocaine use disorder

Motivation: Neuroimaging improves treatment response classification in cocaine use disorder (CUD), often relying on brain morphometry to track changes. Multiple studies report that MRI textural changes predict earlier changes than volumetric changes in Alzheimer’s disease. We aim to apply textural analysis to multi-timepoint CUD MRI data.

Goal(s): Our work investigates changes in the amygdala volume and texture in CUD patients undergoing repetitive transcranial magnetic stimulation (rTMS).

Approach: We computed the volumetric and textural changes over time and compared the relative temporal sensitivities.

Results: The relative temporal sensitivity of textural changes in the amygdala is higher than volumetric changes in CUD patients undergoing rTMS.

Impact: Textural changes in MRI become noticeable before volumetric changes, offering additional insights into ongoing therapy complementary to clinical measures. This allows for personalized treatment, utilizing each individual's baseline data as their internal reference.

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