Keywords: Data Processing, Quantitative Susceptibility mapping, Brain
Motivation: The contribution of physiologically induced dynamic magnetic susceptibility within the brain to the blood oxygen level dependent (BOLD) signal used for functional imaging has never been quantified.
Goal(s): Our goal was to measure the brain’s dynamic magnetic susceptibility signal as a function of the cardiac and respiratory cycles using quantitative susceptibility mapping (QSM).
Approach: We developed and evaluated an image processing framework to generate dynamic susceptibility maps over the course of cardiac pulsation and respiration.
Results: We demonstrated that QSM is sensitive to physiologically induced susceptibility changes and that our framework can be used to measure these dynamics.
Impact: The influence of physiologically induced dynamic magnetic susceptibility on BOLD signal could impact the derivation/interpretation of BOLD-based functional connectivity. Significant susceptibility changes could indicate a need to modify existing functional mapping approaches whereas the reverse would validate current techniques.
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