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Abstract #3124

Layer ReHo: Tool for characterizing mesoscale functional structure across layers and columns

Burak Akin1, Richard Klein1, Kenshu Koiso2, Yinghua Yu3, JiaJia Yang3, Renzo Huber1, and Peter Bandettini1
1NIMH, NIH, Bethesda, MD, United States, 2Faculty of Psychology and Neuroscience, Maastricht, Netherlands, 3Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan

Synopsis

Keywords: Functional Connectivity, High-Field MRI, layer fMRI, ReHo

Motivation: High resolution fMRI is an emerging field, analysis pipelines are still under development. Local and short distanced time course similarities also named as Layer dependent regional homogeneity, can give us insights to map laminar dependent signal differences.

Goal(s): Using a simple metric to color code the depth dependent cortical activity.

Approach: Using mesoscale functional structure to predict and understand, time locked activity patterns in cortical ribbon without having necessity of specific model or predefined ROI

Results: Layer dependent regional homogeneity predicts local activity patterns, also can be used as a similarity matrix to rank different runs which potentially contributes to similar layer patterns.

Impact: This work can potentially be a publicly available analysis tool to observe and quality check, can also quantify laminar separability of the acquired depth dependent high resolution fMRI data.

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Keywords