Keywords: fMRI Acquisition, fMRI, layer-fMRI, UHF, EPI, VASO, sub-millimeter fMRI, 7 tesla
Motivation: Layer-fMRI can address questions of directional information flow, but it’s difficult in lower brain areas.
Goal(s): We want to make layer-fMRI work in low brain structures, despite commonly low tSNR, EPI distortions, and EPI phase errors.
Approach: We tested the efficacy of four advanced acquisition approaches to mitigate these challenges: pTx, dual-polarity readouts, multi-shot segmentation, and aggressive GRAPPA.
Results: We found that pTx and high GRAPPA had limited impact for improved image quality. Though, multi-shot segmentation and dual-polarity readouts allowed layer-fMRI applications in low brain areas.
Impact: This work helps to fulfill the promise of layer-fMRI beyond the top 50% of the cortex.
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