Abstract #3131

Unveiling Mesoscale Finger-specific Neural Circuits through Near-infrared Stimulation and fMRI Mapping

Boyi Qu^1,2,3, Tingting He^1,2,3, Haiming Wang^1,2,3, Zheng Tang^2,3, Zhuyuan Lyu^2,3, Anna W. Roe*^1,2,3, and Hsin-Yi Lai*^1,2,3

¹College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China, ³MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-machine Intelligence, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Functional Connectivity, Neuroscience

Motivation: The dexterity of individuated finger movements is fundamental to daily hand use; yet specific brain networks serving each finger remains poorly understood.

Goal(s): Our objective is to unravel mesoscale connections associated with finger-specific neural circuits.

Approach: In 2 macaque monkeys, single digit locations were functionally mapped in cortical areas 3b via fMRI. Pulsed INS (infrared neural stimulation) targeted to these sites elicited mesoscale BOLD activation at functionally connected sites resulting in brainwide single digit networks.

Results: INS-induced BOLD activations revealed the distinct networks associated with each finger. Index finger connected with sensorimotor, multisensory and emotion circuits, supporting flexibility and stability in fine movement.

Impact: This research identifies specific brain networks underlying single digit maps in SI, and will be relevant for understanding hand dexterity, neurorehabilitation, and prosthesis development.

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