Keywords: fMRI Acquisition, fMRI, Laminar fMRI
Motivation: To explore the potential of layer-specific imaging of the brain at standard clinical field (3T) and ultra-high field strengths (7T)
Goal(s): To assess the feasibility of sub-millimetre BOLD fMRI at 3T compared to 7T and characterise activation maps and laminar profiles
Approach: 12 healthy participants scanned using product 2D-EPI at four resolutions on both 3T and 7T scanners. Data were meticulously processed using ANTs and AFNI following NORDIC-PCA denoising.
Results: We demonstrate that sub-millimetre GE-BOLD fMRI at 3T is feasible using a standard fMRI sequence, has sufficient tSNR and reliable BOLD activation maps.
Impact: Our work broadens accessibility to high-resolution fMRI at 3T. Thus, encouraging new directions in neuroimaging and enabling a deeper understanding of human brain function in health and disease, impacting not only neuroscientists but also the broader scientific and medical communities.
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