Keywords: Functional Connectivity, fMRI (resting state)
Motivation: The motivation is to explore the influence of onset age on large-scale brain networks in MDD patients.
Goal(s): The purpose of this study is to explore the shared and unique alterations of large-scale network connectivity between adolescent-onset and adult-onset MDD.
Approach: This was a single-center cross-sectional study. Volunteers underwent R-fMRI scans. The 2×2 ANOVA was used to analyze the main effects of diagnosis, age and their interaction effect on FCs.
Results: Adolescent-onset and adult-onset MDD have shared and unique large-scale network alterations. The shared altered FCs included VN, LN, VN-DAN VN-LN and LN-DMN. The unique altered FCs included DAN and LN.
Impact: Our findings provide the physiological mechanisms of adolescent-onset and adult-onset MDD for improving clinical subtyping and treatment strategies. The results also suggested that when we explore biomarkers of MDD, we should include onset age as a consideration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords