Abstract #3152

Comparison of the spatial distribution of BOLD Regional Homogeneity (ReHo) and Cerebral Blood Flow at rest

Davide Di Censo^1,2, Antonio Maria Chiarelli^1,2, Eleonora Patitucci³, Michael Germuska⁴, Stefano Censi^1,2, Francesca Graziano^1,2, Emma Biondetti^1,2, Alessandra Stella Caporale^1,2, Valentina Tomassini^1,2,3, and Richard Geoffrey Wise^1,2,3

¹Institute of Advanced Biomedical Technology (ITAB), "D'Annunzio" University of Chieti-Pescara, Chieti, Italy, ²Department of Neuroscience, Imaging, and Clinical Sciences, "D'Annunzio" University of Chieti-Pescara, Chieti, Italy, ³Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Data Processing, Brain Connectivity

Motivation: Regional Homogeneity (ReHO) of BOLD signal is a potential marker of brain activity at rest. CBF is coupled to metabolism in the human brain and it can be used to investigate the physiological significance of ReHo.

Goal(s): We aimed to assess the spatial correlation between ReHo and ASL-derived CBF and its temporal stability.

Approach: Twenty subjects underwent 28 minutes of simultaneously acquired BOLD-ASL resting-state fMRI. CBF and ReHo spatial associations at different times were estimated and compared.

Results: We found a modest but stable and significant spatial correlation between CBF and ReHo.

Impact: This study could be significant for diagnosis and treatment of neurological disorders. If ReHo is demonstrated to be a reliable marker of local brain metabolism, it could be used to develop new fMRI methods for detecting and monitoring brain disorders.

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