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Abstract #3169

Contribution of coupling task-functional-MRI and kinematic to the analysis of motor function in healthy subjects

Zakaria Belkacemi1,2,3, Liesjet van Dokkum1, Thomas Troalen2, Andon Tchechmedjiev3, Nicolas Menjot De Champfleur1,4, Isabelle Laffont1,3, Denis Mottet3, and Emmanuelle Le Bars1
1Neuroradiology, Montpellier University Hospital, Montpellier, France, 2Siemens Healthineers, Courbevoie, France, 3Euromov Digital Health in Motion, Montpellier, France, 4Laboratoire Charles Coulomb, Montpellier, France

Synopsis

Keywords: fMRI Analysis, fMRI (task based), motor control

Motivation: There is a lack of understanding of the mechanisms of post-stroke motor recovery. To date, fMRI brings information which are not linked to the movement characteristics.

Goal(s): To investigate whether integration of kinematic in fMRI adds any value to the understanding of motor function.

Approach: A block designed motor-task-fMRI experiment coupled with real-time motion-tracking was performed on sixteen healthy subjects. Post-processing consisted of a group-level analysis comparing the regression of the BOLD signal with action-rest onsets, and with the flexion velocity vector.

Results: Using a wider cluster-size, kinematic approach allows retrieving regions found with conventional approach and additional regions involved in motor control.

Impact: Coupling of fMRI with kinematics provides additional information on motor function and motor control. Post-stroke motor recovery is subject to variability and is linked to motor control. Coupling both measurements could provide better understanding of motor recovery at the individual-level.

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Keywords