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Abstract #3172

Acute changes of cerebral hemodynamics, metabolism and blood-brain barrier permeability in response to aerobic exercise

Yizhe Hu1, Wen Shi2, Dengrong Jiang2, Hanzhang Lu2, Dan Wu1, and Zixuan Lin1
1Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Oxygenation, Oxygenation

Motivation: How does single bout of exercise affect brain oxygen metabolism and BBB permeability in addition to perfusion remains unclear.

Goal(s): This study aims to dynamically monitor the acute changes in cerebral physiology subsequent to a singular aerobic exercise training session

Approach: Multiple indices were quantified, including CBF as gauged by PC MRI, Yv and CMRO2 as assessed by TRUST MRI, BBB E and PS as determined via WEPCAST MRI.

Results: We found a significant increase in participants' CBF and CMRO2 post-exercise, post-exercise stability in E and a significant increase in PS were also observed.

Impact: Our findings suggest that a singular bout of moderate-intensity aerobic exercise can induce acute alterations in cerebral hemodynamics, metabolic processes, and blood-brain barrier permeability.These findings may shed light on the initial stages of the clinical implications of aerobic exercise.

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Keywords

exerciseaerobicbloodbraincerebralpermeabilityoxygentrainingparticipantsdurationmetabolicoxygenationminutesfindings