Abstract #3172

Acute changes of cerebral hemodynamics, metabolism and blood-brain barrier permeability in response to aerobic exercise

Yizhe Hu¹, Wen Shi², Dengrong Jiang², Hanzhang Lu², Dan Wu¹, and Zixuan Lin¹

¹Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Oxygenation, Oxygenation

Motivation: How does single bout of exercise affect brain oxygen metabolism and BBB permeability in addition to perfusion remains unclear.

Goal(s): This study aims to dynamically monitor the acute changes in cerebral physiology subsequent to a singular aerobic exercise training session

Approach: Multiple indices were quantified, including CBF as gauged by PC MRI, Y_v and CMRO₂ as assessed by TRUST MRI, BBB E and PS as determined via WEPCAST MRI.

Results: We found a significant increase in participants' CBF and CMRO₂ post-exercise, post-exercise stability in E and a significant increase in PS were also observed.

Impact: Our findings suggest that a singular bout of moderate-intensity aerobic exercise can induce acute alterations in cerebral hemodynamics, metabolic processes, and blood-brain barrier permeability.These findings may shed light on the initial stages of the clinical implications of aerobic exercise.

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