Keywords: Oxygenation, Oxygenation, qBOLD
Motivation: To investigate sources of error in a new quantitative BOLD technique incorporating an independent measure of deoxygenated blood volume.
Goal(s): Simulate the effect of systematic error and system noise on estimates of oxygen extraction fraction.
Approach: Monte Carlo simulations of the random walk of protons around deoxygenated blood vessels modelled as infinite cylinders were performed using a standard approach.
Results: These simulations show that introducing an independent measure of DBV into the qBOLD framework provides improved estimates of oxygen extraction fraction.
Impact: This improved technique for mapping oxygen extraction has wide applications in the study of neurological disorders including stroke, dementia and cancer.
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