Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), asthma, gas-exchange, MRS, lung
Motivation: 129Xe MRS quantifies pulmonary gas-exchange by probing inhaled 129Xe transfer from the alveolar-membrane to the red-blood-cells (RBC). Recent work suggested a vascular response to asthma therapy, quantifiable using 129Xe MRS.
Goal(s): We aimed to examine if 129Xe MRS measurements were predictive of significant 6-week response to ICS/LAMA/LABA in moderate asthma patients.
Approach: 129Xe MRS and pulmonary function measurements were acquired prior to and following 6-weeks of therapy.
Results: 129Xe RBC:membrane, measured prior to treatment, was predictive of response to ICS/LAMA/LABA at 6 weeks, measured using the fraction-of-exhaled nitric-oxide and the ratio of forced-expiratory-volume in 1-second to forced-vital-capacity.
Impact: For the first time, 129Xe MRS RBC:membrane has been shown to predict early (6-week) response to ICS/LAMA/LABA in moderate asthma. 129Xe MRS uncovered a novel pathophysiology in asthma patients, with potential for consideration as a new treatable target.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords