Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Keyhole-based 129Xe MR imaging of cardiopulmonary oscillations is a promising technique, but repeatability has not been studied.
Goal(s): To evaluate the repeatability of RBC oscillation amplitude metrics derived from 129Xe MRI across multiple time points and correlate these with dynamic spectroscopy measurements.
Approach: A cohort of 21 participants underwent 129Xe gas exchange MRI and MRS scans using consortium protocols. Repeatability was assessed using Bland-Altman analysis, with Spearman correlation for cross-modality comparison
Results: The study found repeatability to be high for mean oscillation amplitude but moderate for the binning-derived metrics. Image-derived mean oscillation amplitude correlated strongly to that derived from MRS.
Impact: Analysis of 129Xe MRI cardiopulmonary oscillation metrics show moderate repeatability across same-session scans.
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