Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Quantitative 129Xe gas exchange MRI, conducted across different imaging centers and scanner platforms, requires consistent healthy reference distributions.
Goal(s): To establish standardized reference values from an 18-30yr old multicenter healthy cohort for 129Xe gas exchange MRI.
Approach: Participants from three research centers underwent pulmonary function tests and a standardized 129Xe MRI/MRS protocol. Data were processed centrally and corrected for T2*.
Results: A balanced multicenter dataset revealed minimal variability between combined and site-specific reference distributions, validating the combined values for cross-center use. The distribution for 208-ppm excitation could be reliably transformed for 218-ppm excitation.
Impact: This study provides robust cross-platform reference distributions for 129Xe gas exchange MRI, facilitating comparison of quantitative imaging in multi-center respiratory research.
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