Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Pulmonary embolism (PE) is a leading cause of cardiovascular death. Timely diagnosis is crucial but challenging. Increasing inspired oxygen levels to 40% or above has proven an effective treatment in acute PE by altering pulmonary gas exchange.
Goal(s): Our goal is to determine if hyperpolarized 129-xenon gas can diagnose PE.
Approach: Hyperpolarized 129-xenon dissolved-phase imaging was evaluated by applying a hyperoxic challenge in a porcine PE model.
Results: Whole lung assessment of dissolved-phase imaging indicates regional pulmonary gas exchange increases with higher inhaled oxygen levels. Nevertheless, hyperoxic challenge effects did not diagnose PE.
Impact: The study shows great potential of a pulmonary gas exchange imaging with the application of dissolved-phase hyperpolarized 129Xe imaging throughout a hyperoxic challenge. Nevertheless, the method did not improve diagnosis of pulmonary embolism in our porcine animal model.
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