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Abstract #3199

129Xe HyperCEST Imaging of a Novel R3-Noria-methanesulfonate Supramolecular Cage using a 3.0 T Clinical MRI

Viktoriia Batarchuk1,2, Yurii Shepelytskyi1,2, Vira Grynko2,3, Antal Halen Kovacs4, Aaron Hodgson5, Karla Rodriguez1, Ruba Aldossary2, Tanu Talwar1, Carson Hasselbrink6, Brenton DeBoef7, and Mitchell S. Albert1,2,8
1Chemistry, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, 4Applied Life Science Program, Lakehead University, Thunder Bay, ON, Canada, 5Physics Program, Lakehead University, Thunder Bay, ON, Canada, 6California Polytechnic State University, San Luis Obispo, CA, United States, 7University of Rhode Island, Kingston, RI, United States, 8Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), xenon-129, HyperCEST, chemical exchange, Noria, R3-Noria-methanesulfonate

Motivation: In the setting of molecular MRI, designing a contrast agent that can be applied in clinical studies and which offers high sensitivity poses a significant challenge.

Goal(s): We aimed to demonstrate a novel water-soluble R3-Noria-MeSO3H macrocycle as a viable supramolecular cage agent for 129Xe molecular imaging.

Approach: Hyperpolarized 129Xe chemical exchange saturation transfer MR imaging and spectroscopy were conducted in vitro using a 3.0T clinical MRI scanner.

Results: We demonstrated that R3-Noria-MeSO3H produces a superior HyperCEST effect and investigated its dependence on concentrations in various aqueous solutions.

Impact: The introduction of the novel R3-Noria-MeSO3H macrocycle for HP 129Xe HyperCEST imaging marks a critical milestone, establishing a new frontier in 129Xe molecular imaging with heightened sensitivity and potential for advancing clinical applications in diagnostic precision and therapeutic monitoring.

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Abstract

Keywords