Keywords: Contrast Agents, Cancer, Simultaneous PET/MRI, 68Ga contrast agent, extracellular pH measurement, 4T1
Motivation: The measurement of extracellular pH (pHe) is very important for studying the cancer development, progression, and therapeutic response.
Goal(s): Accurately measure the pHe for 4T1 tumor and 0.2 pH change in vitro independent on the concentration of MRI contrast reagent.
Approach: To co-inject the synthesized pH sensitive MRI contrast reagent and the PET reagent with the same pharmacokinetic functions and DCE MRI and dynamic PET scan were obtained simultaneously.
Results: The pHe change of the bicarbonate treatment for the acidosis tumor type can be measured by our PET/MRI co-inject reagent.
Impact: PET/MRI co-inject reagent makes it possible for the pHe measurement independent of the concentration of MRI contrast reagent.
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