Abstract #3212

Comparison of Relaxivity and Image Quality of Brand name vs Generic Ferumoxytol: phantom and in vivo results

Rianne A van der Heijden^1,2, Daiki Tamada¹, James Rice^1,3, and Scott B Reeder^1,4,5,6,7

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, ³Mechanical engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Contrast Agents, Vessels, Vascular

Motivation: Ferumoxytol is a superparamagnetic iron-oxide agent increasingly used for MR angiography. Cost can potentially be reduced by using a newly introduced generic ferumoxytol, so long as the relaxivity and image quality are similar.

Goal(s): To compare the relaxivity and image quality of brand name ferumoxytol (Feraheme®, AMAG Pharmaceuticals) with generic ferumoxytol (Sandoz), and determine optimal dose and acquisition parameters.

Approach: Phantom experiment and in-vivo dose accumulation with flip angle optimization, using an intra-individual cross-over design.

Results: No clinically relevant differences in relaxivity and MR angiography image quality were observed between ferumoxytol agents. The optimal flip angle and dose are 20° and 5mg/kg, respectively.

Impact: Brand name ferumoxytol (Feraheme®, AMAG Pharmaceuticals) and generic ferumoxytol (Sandoz) are interchangeable for MR angiography. The use of a generic agent may lead to reduction in cost.

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