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Abstract #3221

Single-patient analysis of quantitative T1 values at 7T reveals global abnormalities in epilepsy

Gian Franco Piredda1,2, Tom Hilbert1,3,4, Samuele Caneschi1, Gabriele Bonanno5,6,7, David Seiffge8, Martina Goeldlin8, Robert Hoepner8, Kaspar Schindler8, Serge Vulliemoz9, Margitta Seeck9, Veronica Ravano1,3,4, Bénédicte Maréchal1,3,4, Roland Wiest6,10, Tobias Kober1,3,4, and Piotr Radojewski6,10
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2CIBM Center for Biomedical Imaging, Geneva, Switzerland, 3Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 4LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 6Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 7Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 8Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland, 9EEG and Epilepsy Unit, Department of Clinical Neurosciences, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland, 10Support Center for Advanced Neuroimaging, Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland

Synopsis

Keywords: Epilepsy, Quantitative Imaging, ultra-high field, 7T MRI

Motivation: While widespread structural changes in epilepsy have been previously reported, the global secondary effects on the brain are yet to be fully understood.

Goal(s): To investigate the presence of global abnormalities in quantitative T1 values in drug-resistant epilepsy at a single-patient level.

Approach: Seventy-eight epilepsy patients were studied using 7T MRI, and a previously established quantitative T1 brain atlas of healthy subjects was used to calculate T1 deviations in patients.

Results: Frontal and temporal gray matter exhibited the largest T1 alterations, with significant correlations observed between T1 deviations and the patients’ disease duration. These findings suggest widespread microstructural disruptions in epilepsy patients.

Impact: The observed quantitative T1 changes reveal widespread microstructural disturbances in epilepsy patients that extend beyond the seizure onset zone. The proposed method may allow early diagnosis of previously undetectable microstructural abnormalities along brain areas involved into seizure formation and propagation.

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Abstract

Keywords