Abstract #3230

Investigating ASL-MRI as a Complementary Modality for 18F-FDG PET in Identifying Mesial Temporal Lobe Epilepsy Laterality in Grey Matter

Mohammad-Reza Nazem-Zadeh¹, Hossein Rahimzadeh ², Hadi Kamkar ³, Narges Hoseini-Tabatabaei ⁴, Sohrab Hashemi-Fesharaki ⁵, and Jafar Mehvari Habibabadi ⁶

¹Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ²Biomedical Engineering and Medical Physics, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of), ³Bioinformatics and Biophysics, Tarbiat Modares University, Tehran, Iran (Islamic Republic of), ⁴Medical School, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁵Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁶Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Islamic Republic of)

Synopsis

Keywords: Epilepsy, Perfusion, ASL-MRI, 18F-FDG PET, Lateralization of TLE

Motivation: Using non-invasive ASL-MRI as a substitute of 18F-FDG PET for identification of epileptogenic zone in mTLE patients

Goal(s): This study aims to check if there is a correlation between the CBF of ASL-MRI and metabolic data from 18F-FDG PET.

Approach: Brain division into 12 ROIs, including key areas like the amygdala and hippocampus, used BASIL and FSL tools for CBF and SUVr extraction. Used Pearson's and Spearman's rank correlation of SPSS for correlation analysis.

Results: Significant CBF and SUVr correlations in middle temporal gyrus, hippocampus, and superior temporal found in mTLE patients.

Impact: This study affects mTLE patients' accurate and rapid epileptogenic foci location.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.