Abstract #3261

Blood-to-CSF Water Exchange Time Estimation Using a multi-PLD, multi-TE 3D RARE Stack-of-Spirals ASL Sequence

Bo Li¹, Hangfan Liu², Yiran Li², Manuel Taso³, Léonie Petitclerc^4,5,6, Matthias J. P. van Osch^4,5,6, Marta Vidorreta⁷, María A. Fernández-Seara^8,9, M. Dylan Tisdall¹⁰, Yulin Chang³, John A. Detre¹¹, and Ze Wang²

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Baltimore, MD, United States, ²Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Baltimore, MD, United States, ³Siemens Healthineers, Philadelphia, PA, United States, ⁴Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵Leiden Institute for Brain and Cognition(LIBC), Leiden, Netherlands, ⁶C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Siemens Healthineers, Madrid, Spain, ⁸Department of Radiology, línica Universidad de Navarra, Pamplona, Spain, ⁹Idisna, Instituto de Investigación Sanitaria de Navarra, Spain, Spain, ¹⁰Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ¹¹Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Pulse Sequence Design, Arterial spin labelling, multiple-TE ASL

Motivation: To assess the blood-CSF barrier on a Siemens platform using a multi-TE 3D RARE stack-of-spirals ASL sequence.

Goal(s): To obtain high-quality fitted blood-to-csf time images.

Approach: A 3D RARE pCASL sequence with multiple-TE acquisitions was used to collect ASL images. To cope with the low SNR issue in blood-CSF barrier ASL imaging, a denoising technique of locally adaptive low rank regularization with collaborative data selection was applied to images.

Results: The fitted blood-to-csf time images generated from denoised control and label images showed significantly improved image quality. The Bland-Altman Plot shows a good agreement between the test and retest scans using the sequence.

Impact: Blood-CSF barrier ASL implemented in the Siemens platform showed good test-retest reliability with the help of advanced denoising. The denoising technique can be used for ASL applications to provide high-quality images.

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