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Abstract #3281

Novel microstate method to identify fMRI networks and assess their dynamic temporal characteristics

Kay Jann1, Dilmini Wijesinghe1, Ru Zhang1, Thomas Koenig2, and Danny JJ Wang1
1USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland

Synopsis

Keywords: fMRI Analysis, Data Analysis, fMRI (resting state), dynamic connectivity, microstate

Motivation: Implement a well-established method (microstate analysis) to characterize state and state-transitions from EEG to fMRI. Such an approach will provide information on dynamic network changes and could provide a novel way to assess brain function in health and disease.

Goal(s): To provide a proof-of-concept that EEG-microstate analysis can be adapted to fMRI.

Approach: Adapt EEG-microstate analysis to fMRI data and characterize dynamic brain network changes.

Results: We demonstrate that this novel approach can identify distinct network states, their average duration, frequency of occurrence, total coverage of entire scan and transition probabilities between states.

Impact: We provide proof-of-concept that commonly used EEG-microstate analysis can be adapted to characterize dynamic changes in brain network states in fMRI data. This novel analysis could provide novel insights in alterations of brain functionality in various disorders.

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Keywords