Abstract #3309

Using PINS pulses to investigate Inflow effects in SE-BOLD fMRI at 3T and 7T

Shota Hodono¹, Chia-Yin Wu^1,2,3, Jonathan R Polimeni^4,5,6, and Martijn A Cloos¹

¹Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ²ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia, ³School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Australia, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: fMRI Acquisition, fMRI, inflow effects

Motivation: Most fMRI techniques infer neuronal activity from signal changes created by a complex interplay between hemodynamics and sequence design parameters.

Goal(s): Investigate inflow effects in SE-BOLD fMRI signals at different field strengths and resolutions.

Approach: We placed PINS pulses to saturate the magnetization in all slice gaps. By turning them on or off, inflow contributions to the SE-BOLD signal were modulated. Both 3- and 1.5-mm data were collected using a visual stimulation paradigm at 3T and 7T.

Results: Inflow contributions to SE-BOLD varied by field strength and partial voluming effects. Even at 7T, non-negligible inflow contributions were observed.

Impact: Saturating the magnetization in slice-gaps allows investigation of inflow effects in SE-BOLD fMRI. Low-resolution 3T-data revealed differences in onset timing. Comparing low- and high-resolution 7T-data with and without slice-gap saturation, increased resolution retained more activation, suggesting reduced sensitivity to inflow.

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