Keywords: Functional Connectivity, fMRI (resting state)
Motivation: Electroencephalography (EEG) and resting-state functional MRI (rs-fMRI) are both critical tools for investigating epilepsy, and their combination will further reveal meaningful insights.
Goal(s): This study investigates the correlation between EEG spikes and functional connectivity in a drug-induced epileptic small-animal model.
Approach: An epileptic animal model was employed by injecting pentylenetetrazol (PTZ) through intraperitoneal to trigger acute epileptic-like abnormal neuron discharges, and EEG and rs-fMRI data were acquired seperately.
Results: This study integrated longitudinal rs-fMRI monitoring and EEG recordings in the same epilepsy animal model to assess drug-induced epileptic signals, showing and increase of both EEG spike numbers and C.C. after inducing epilepsy drug.
Impact: This study demonstrate the potential of brain region-to-region connectivity becoming a new bio marker of epilepsy diagnosis. However, greater precision and repeatablility of fMRI measurements is required for future studies to accurately align fMRI data with the electrophysiological data.
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