Abstract #3315

Targeting Motor and Cognitive Impairments: Comparative Insights into STN-DBS and NAc-DBS Efficacy in Parkinson's Disease Model with Metabolism

Ssu-Ju Li¹, Yi-Chun Lee², Ting-Chieh Chen¹, Yu-Chun Lo³, Ching-Wen Chang¹, Yao-Wen Liang¹, Yi-Chen Lin¹, Yun-Ting Liu¹, Sheng-Huang Lin^4,5, and You-Yin Chen^1,3

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ³PhD Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ⁴Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ⁵Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Functional Connectivity, Parkinson's Disease, deep brain stimulation

Motivation: Addressing subthalamic nucleus deep brain stimulation (STN-DBS) limitations in Parkinson's Disease (PD), such as metabolic disorder and cognitive dysfunction. We explored nucleus accumbens deep brain stimulation (NAc-DBS) as an alternative, aiming to enhance motor, cognitive, and metabolic functions comprehensively.

Goal(s): Investigate NAc-DBS effectiveness, bridging STN-DBS gaps, enhancing motor skills, and improving cognitive and metabolic functions in PD.

Approach: Utilized behavioral tests, brain magnetic resonance imaging analysis, and bioenergetic analysis to evaluate NAc-DBS and STN-DBS impact on the MitoPark PD mouse model.

Results: NAc-DBS significantly enhanced cognitive, motor functions, and energy metabolism, offering a promising therapeutic solution for PD patients.

Impact: Our findings transform Parkinson's treatment, sheding a light to patients. The dual benefits of NAc-DBS inspire new inquiries, reshaping therapies with metabolic modulation. Improved outcomes redefine standards, offering hope for enhanced quality of life.

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