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Abstract #3320

9.4T MR based rs-fMRI of anesthetized mice after passive hyperthermia

Yang Ruan1, Kai Liu2, Bo Li2, Hongxia Lei1, Yao Xing1, and Gang Sun2
1Wuhan United Imaging Life Science Instruments Ltd.,, Wuhan, China, 2960th Hosp Joint Logist Support Force PLA, Dept Radiology, Jinan, China

Synopsis

Keywords: Functional Connectivity, Neuroscience

Motivation: The effects of passive hyperthermia on brain function in resting-state mice are unknown.

Goal(s): To expiore the rs-fMRI in hyperthermia treated and normal mice brain.

Approach: The ICA network and ROI-ROI FC in passive hyperthermia mice brain were compared with normal control.

Results: The ICA networks changed and the overall ROI-ROI FC of the passive hyperthermia mice decreased.

Impact: After prolonged exposure to high temperature has a greater impact on the overall perception and cognitive level of mice, which might help understand the relationship between neuronal activities and physiological thermal sensation and regulation as well as behavioral changes.

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Keywords