Abstract #3324
How Variable Are Our Rat Sensory-Evoked Functional MRI Datasets?
Marie E Galteau1,2, Sung-Ho Lee3, Margaret Broadwater4, Yi Chen5, Gabriel Desrosiers-Gregoire6,7, Yujian Diao8,9, Rita Gil10, Johannes Kaesser11, Eugene Kim12, Henriette Lambers13, Yanyan Y Liu14, Eilidh MacNicol12, Henning M Reimann15, Erwan Selingue16, Noam Shemesh10, Nikoloz Sirmpilatze17,18,19, Sandra Strobelt11, Akira Sumiyoshi20,21, Isabel Wank11, Yongzhi Zhang22, Jürgen Baudewig17, Susann Boretius19,23,24, Diana Cash12, M Mallar Chakravarty6,25,26, Kai-Hsiang Chuang27, Luisa Ciobanu16, Gabriel A Devenyi6,26, Cornelius Faber13, Andreas Hess11, Judith R Homberg1, Ileana O Jelescu8, Carles Justicia28, Ryuta Kawashima29, Thoralf Niendorf15,30, Tom WJ Scheenen2,31, Guadalupe Soria32, Nick Todd22, Lydia Wachsmuth13, Xin Yu5,33, Baogui B Zhang34, Yen-Yu Ian Shih4, and Joanes Grandjean1,2
1Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, Netherlands, 2Department for Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands, 3Center for Animal MRI, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 4The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 5High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 6Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, QC, Canada, 7Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada, 8Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland, 9Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 10Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 11Institute of Experimental and Clinical Pharmacology and Toxicology, FAU Erlangen-Nürnberg, Erlangen, Germany, 12Department of Neuroimaging, King's College London, London, United Kingdom, 13Clinic of Radiology, University Hospital Münster, Muenster, Germany, 14Brainnetome CenterBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Brainnetome CenterBrainnetome Center, China, 15Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 16NeuroSpin, CEA Saclay, Paris, France, 17Functional Imaging Laboratory, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany, 18Faculty of Biology and Psychology, Georg-August University of Göttingen, Göttingen, Germany, 19DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany, 20Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 21National Institutes for Quantum Science and Technology, Chiba, Japan, 22Radiology, Brigham and Women's Hospital, Boston, MA, United States, 23Faculty of Biology and Psychology, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany, 24Georg-August University of Göttingen, Göttingen, Germany, 25Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, 26Department of Psychiatry, McGill University, Montreal, QC, Canada, 27Queensland Brain Institute and Centre for Advanced Imaging, University of Queensland, St Lucia, Australia, 28Instituto de Investigaciones Biomédicas de Barcelona (IIBB), Instituto de Investigaciones Biomédicas de Barcelona (IIBB), Barcelona, Spain, 29Institute of Development, Aging and Cancer, Tohoku University, Sendai, Korea, Republic of, 30Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 31Erwin L. Hahn Institute for MR ImagingErwin L. Hahn Institute for MR Imaging, University of Duisburg-Essen, Essen, Germany, 32Institute of Neuroscience, University of Barcelona, Barcelona, Spain, 33Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 34Brainnetome CenterBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Synopsis
Keywords: fMRI Acquisition, Brain, rats, multicenter, sensory-evoked, heterogeneity
Motivation: We address the need for standardization and collaboration in rat sensory-evoked fMRI by providing evidence-based recommendations and open-access datasets, fostering community growth.
Goal(s): We aim to assess inter- and intra-datasets variability, focusing on image acquisition and experimental protocols, and to optimize analysis by comparing hemodynamic response functions and denoising methods.
Approach: We collected 17 rat datasets from 10 centers, applied standardized preprocessing, and analyzed the sensory-evoked responses at individual and groups levels. Project code is openly available.
Results: Our study revealed significant diversity in rat attributes, anesthesia protocols, and imaging acquisition parameters across datasets. We are currently optimizing analyses to strengthen protocol robustness.
Impact: We present evidence for the substantial heterogeneity intra- and inter-datasets of rat sensory-evoked fMRI. We will provide guidelines to enhance reproducibility, facilitate cross-laboratory comparisons, collaborations in neuroimaging research, and encourage more robust findings with potential translational applications.
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