Abstract #3357

Investigating Brain Health in Coronary Artery Disease: Vascular and Metabolic Biomarkers, Cognition, and Implications

Safa Sanami^1,2, Stefanie Tremblay^1,2, Dalia Sabra^1,2, Ali Rezaei^1,2, Zacharie Potvin-Jutras^1,2, Brittany Intzandt³, Julia Huck^4,5, Christine Gagnon², Amelie Mainville-Berthiaume⁶, Linsay N Wright^1,2, Dajana Vuckovic⁷, Josep Iglesies-Grau^2,8, Thomas Vincent², Mathieu Gayda², Anil Nigam², Louis Bherer^2,8,9, and Claudine J Gauthier^1,2

¹Physics, Concordia University, Montreal, QC, Canada, ²Montreal Heart Institute, Centre Epic and Research center, Montreal, QC, Canada, ³Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Department of Radiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Department of Psychology, Concordia University, Montreal, QC, Canada, ⁷Department of Chemistry and Biochemistry, Concordia University, Montreal, QC, Canada, ⁸Department of Medicine, Université de Montreal, Montreal, QC, Canada, ⁹Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC, Canada

Synopsis

Keywords: Vascular, Brain

Motivation: There is limited understanding regarding the physiological mechanisms underlying the impact of coronary artery disease (CAD) on brain health.

Goal(s): In this study, we sought to explore the influence of CAD on vascular and metabolic biomarkers.

Approach: Specifically examining Cerebrovascular Reactivity (CVR), Cerebral Blood Flow (CBF), and Oxygen Extraction Fraction (OEF) in the brain, and how these factors relate to cognitive performance.

Results: Our initial findings, based on a preliminary dataset, indicate that individuals with CAD exhibit reduced CBF and CVR, with increased OEF across several brain regions. Low CVR and high OEF are also associated with poorer executive function in these regions.

Impact: The influence of coronary artery disease (CAD) on brain health remains unclear. We show that CAD is associated with elevated OEF and reduced CVR and CBF. High OEF and low CVR are linked to poorer cognition, especially executive functions.

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