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Abstract #3361

Comparison of iNAV-based Free-Breathing Non-Contrast Coronary Magnetic Resonance Angiography Acquired at 0.7mm3 and 0.9mm3 Resolution

Simon J. Littlewood1, Gregory Wood2,3, Karl P. Kunze4, Michael G. Crabb1, Won Yong Kim3, Claudia Prieto1,5, and René M. Botnar1,5,6
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark, 3Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Synopsis

Keywords: Atherosclerosis, Atherosclerosis, Angiography, whole-heart

Motivation: Coronary artery disease remains a significant problem worldwide and current methods for anatomical assessment involve ionising radiation and iodinated contrast agents.

Goal(s): To develop a novel free-breathing, 3D whole-heart, coronary magnetic resonance angiography sequence with high spatial resolution for the assessment of coronary anatomy and coronary artery disease.

Approach: Nine patients referred for assessment of suspected coronary artery disease were scanned using the proposed sequence at 1.5T. Acquisitions at 0.9mm3 and 0.7mm3 were compared.

Results: The 0.7mm3 acquisition demonstrated improved qualitative and semi-quantitative vessel visualisation and coronary stenosis detection compared with 0.9mm3 acquisition in an average scan time of <14 minutes.

Impact: This work demonstrates improved coronary artery lumen visualisation and stenosis detection compared to 0.9mm3 acquisitions, providing a further step forward towards clinical adoption as a contrast- and radiation-free alternative to CTCA.

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Abstract

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