Abstract #3375

Non-invasive estimation of relative pressure in the murine aortic arch using virtual work-energy (vWERP)

Patrick Winter^1,2,3, Kristina Andelovic⁴, Thomas Kampf^3,5, Volker Herold³, Alma Zernecke⁶, Peter Michael Jakob³, Wolfgang Rudolf Bauer⁷, David Marlevi^8,9, and Susanne Schnell^1,2

¹Department of Medical Physics, University of Greifswald, Greifswald, Germany, ²Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ³Experimental Physics V, University of Wuerzburg, Wuerzburg, Germany, ⁴Department of Functional Materials in Medicine and Dentistry, University of Wuerzburg Institute of Functional Materials and Biofabrication (IFB), Wuerzburg, Germany, ⁵Department of Diagnostic and Interventional Radiology, University Clinics Wuerzburg, Wuerzburg, Germany, ⁶Institute of Experimental Biomedicine, University Clinics Wuerzburg, Wuerzburg, Germany, ⁷Department of Medical Clinic and Policlinic I, University Clinics Wuerzburg, Wuerzburg, Germany, ⁸Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden, ⁹Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Flow, Blood vessels

Motivation: MRI-based relative pressure is a promising imaging biomarker. A new technique, vWERP, improves pressure estimations compared to more simplified approaches. Validated in clinical settings, it's unexplored in mouse models.

Goal(s): To apply the vWERP algorithm to MRI-microscopy for pressure measurements in wild-type and atherosclerotic mouse models.

Approach: 4D flow MRI was performed in wild-type and ApoE^-/- mice. Post-processing involved segmenting the aorta, defining analysis planes, and calculating pressure drops using the vWERP algorithm for analysis.

Results: Using vWERP with 4D flow MRI shows promise for studying vascular disease hemodynamics. Preliminary findings suggest pressure as a robust parameter to examine changes in CVD progression.

Impact: Application of vWERP to MRI-microscopy in mice reveals high potential for assessing cardiovascular disease progression, particularly in studying pressure changes. This new diagnostic tool benefits vascular health studies in preclinical settings and may be used to study atherosclerotic plaque development.

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