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Abstract #3385

Fibrous cap status, plaque surface morphology, and intraplaque hemorrhage volume over two years in patients with carotid plaques: PARISK study

Mohamed Kassem1,2, Tahnee Gorissen2, Mohammad Albenwan2, Dianne H.K. van Dam-Nolen3, Madieke I Liem4, Paul AM Hofman2, Joachim E E Wilberger1,2, Jeroen Hendrikse5, Werner Mess6, Paul J J Nederkoorn4, Daniel Bos3,7, Patty Nelemans8, Robert J. van Oostenbrugge1,9, and M Eline Kooi1,2
1Cardiovascular Research Institute Maastricht (CARIM), MAASTRICHT, Netherlands, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, MAASTRICHT, Netherlands, 3Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 4Department of Neurology, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 5Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 6Department of Clinical Neurophysiology, Maastricht University Medical Center, maastricht, Netherlands, 7Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 8Department of Epidemiology, Maastricht University, maastricht, Netherlands, 9Department of Neurology, Maastricht University Medical Center, MAASTRICHT, Netherlands

Synopsis

Keywords: Atherosclerosis, Atherosclerosis, Carotid, Stroke

Motivation: We explored the relationship between intraplaque hemorrhage (IPH) and thin/ruptured fibrous cap (TRFC) or disrupted plaque surface.

Goal(s): We investigated the relationship between a TRFC/disrupted plaque surface and the change in carotid IPH volume

Approach: Longitudinal carotid MR study in 110 symptomatic patients with mild-to-moderate carotid stenosis.

Results: Baseline MR images revealed a larger IPH volume in patients with a TRFC/disrupted plaque surface and the IPH volume (tended to) decrease during follow-up. However, part of patients with a TRFC/disrupted plaque surface at baseline had a higher risk of IPH progression.

Impact: Identifying patients at higher risk of IPH progression allows for timely monitoring and intervention, potentially reducing the incidence of stroke. This research contributes to improved quality of life for individuals at risk of carotid IPH-related complications

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Abstract

Keywords