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Abstract #3401

Cardiac MRI markers are associated with adverse clinical outcomes in neonates after congenital diaphragmatic hernia repair

Narine Mesropyan1, Florian Kipfmueller2, Alexander Isaak2, Dmitrij Kravchenko2, Leon Bischoff2, Andreas Mueller2, Ulrike Attenberger2, and Julian Luetkens2
1Department of Diagnostic and Interventional Radiology, University Hospital Bonn, 53121, Germany, 2University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: Heart Failure, Cardiovascular

Motivation: The triad of pulmonary hypoplasia, pulmonary hypertension, and early cardiac dysfunction has been postulated to be responsible for poor postnatal outcomes in congenital diaphragmatic hernia repair (CDH).

Goal(s): This study was aimed to investigate whether MRI markers of cardiac dysfunction are associated with clinical outcomes in neonates after CDH.

Approach: In this prospective study neonates after CDH repair underwent 3T cardiac MRI. Biventricular function/volumes, end-diastolic/end-systolic volumes, shunt fraction were assessed. The study cohort was binarized based on median RVEF (cutoff >54%) to compare clinical variables and outcome data between two groups.

Results: MRI-derived parameters of RV-dysfunction were associated with short-term clinical outcomes.

Impact: Cardiac MRI allows for objective and early assessment of cardiac dysfunction and, hence, might play an important role in risk stratification and clinical decision-making in neonates after CDH repair.

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