Abstract #3410

T1-weighted fMRI in mouse visual cortex at 0.1 mm resolution using a UTE sequence after iron-oxide contrast injection

Naman Jain^1,2, Saskia Bollmann¹, Kai-Hsiang Chuang³, Jonathan R. Polimeni^4,5,6, and Markus Barth^1,2,7

¹School of Electrical Engineering and Computer Science, The University of Queensland, St. Lucia, Australia, ²Centre for Advanced Imaging, The University of Queensland, St. Lucia, Australia, ³Queensland Brain Institute, The University of Queensland, St. Lucia, Australia, ⁴Athinoula A. Martinos Centre for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁶Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁷ARC Centre for Innovation in Biomedical Imaging and Technology, The University of Queensland, St. Lucia, Australia

Synopsis

Keywords: Task/Intervention Based fMRI, Contrast Agent, CBV, Data Acquisition, Data Analysis

Motivation: Conventional use of typical T2* weighted sequences such as FLASH post iron-oxide contrast injection exhibits an enhanced microvascular weighting but neglects changes in pial vessels due to strong dephasing defects.

Goal(s): Our goal is to study changes in the pial vessels which will hopefully aid in the interpretation of non-BOLD fMRI signals and help us understand the CBV fMRI signal at a deeper level.

Approach: We utilised a radial UTE sequence post-contrast injection with short TE and short readout duration

Results: We found consistent positive signal changes in the visual cortex and pial surface.

Impact: We found positive signal changes at the pial surface and in the visual cortex upon stimulation. This might indicate the involvement of both micro- and macrovasculature and provide further insights into cerebral-blood-volume changes across vascular compartments.

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