Abstract #3421

Submillimeter Whole-Brain VASO fMRI using a View-Sharing with Temporal Random Walk at 7 Tesla

Suhyung Park¹, Suvi Häkkinen², Alexander Beckett³, Erica Walker³, Samantha Ma⁴, and David Feinberg^2,3

¹Chonnam National University, Gwangju, Korea, Republic of, ²University of California, Berkeley, Berkeley, CA, United States, ³Advanced MRI Technologies, Sebastopol, CA, United States, ⁴Siemens Medical Solutions USA, Inc, Berkeley, CA, United States

Synopsis

Keywords: fMRI Acquisition, Brain, functional MRI

Motivation: Cerebral blood volume (CBV) fMRI has inherent limitations regarding its imaging efficiency, restricting the spatial volume coverage and spatiotemporal resolution

Goal(s): To improve imaging efficiency for whole-brain VASO fMRI with high temporal resolution

Approach: we introduce a view sharing approach combined with flexible temporal encoding

Results: Proposed method achieves whole-brain VASO and BOLD imaging in 8.3 seconds, while resulting in higher VASO and BOLD activations with high sensitivity

Impact: We confirmed that 1) a view-sharing approach allows VASO and BOLD signal detection without contrast confounding and 2) the random encoding coupled with view sharing significantly improves the imaging efficiency by achieving an 8.3 second whole-brain VASO imaging.

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