Keywords: fMRI Acquisition, fMRI, sliding-window, high temporal resolution, BOLD
Motivation: Higher temporal resolution in fMRI has been increasingly sought after, primarily because of a greater interest in the high-frequency components of BOLD, but also because high temporal resolution is essential to get rid of physiological artifacts.
Goal(s): In light of this mounting interest, we explore the sliding-window approach to improve the temporal resolution, specifically using SPARKLING fMRI.
Approach: A simulation study is conducted for 2D BOLD fMRI at realistic SNR.
Results: It demonstrates the possibility through the sliding window approach to detect oscillations beyond 0.2Hz in the BOLD response and separate the physiological noise from the neural activity.
Impact: Such a strategy can be extended to 3D imaging in a straightforward manner, thereby making whole-brain high spatiotemporal resolution fMRI feasible.
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