Keywords: fMRI Acquisition, fMRI
Motivation: There are reports that line-scan MRI methods can directly measure neural activity (the DIANA response).
Goal(s): In light of replication failures, we sought to understand the noise profile of the line-scan acquisition.
Approach: Using the line-scan protocol (3T GE UHP scanner, N=5) we measured human visual cortex while subjects viewed a blank screen.
Results: The noise has a 1/f temporal spectrum that can be confused with certain stimulus-driven responses. This noise spreads into the surrounding volume in the phase-encoding direction. We explain the pattern of results with a model of the sequence that incorporates time-varying contrast fluctuations.
Impact: Line-scan MRI is particularly susceptible to physiological noise because of its long acquisition time to create a single image. For this reason, the sequence will have difficulty measuring small contrast fluctuations due to neural electrical activity.
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