Abstract #3418

Multi-echo fMRI at 7T in infants

Julia Moser¹, Kimberly B Weldon¹, Sooyeon Sung^1,2, Alireza Sadeghi-Tarakameh³, Thomas J Madison¹, Hannah Pham^1,4, Jacob T Lundquist¹, Edward Auerbach³, Gregor Adriany³, Yigitcan Eryaman³, Steven M Nelson^1,5, Damien A Fair^1,2,5, Jed T Elison^1,2, and Essa Yacoub³

¹Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States, ²Institute of Child Development, University of Minnesota, Minneapolis, MN, United States, ³Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁴Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States, ⁵Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: fMRI Acquisition, High-Field MRI, Infants, multi-echo EPI, 7T, functional connectivity, developmental neuroimaging

Motivation: Imaging infants with traditional voxel sizes is suboptimal due to their smaller brains. 7T imaging allows for higher spatial resolutions, while multi-echo fMRI provides optimal contrast across the brain.

Goal(s): Establish the feasibility of high-resolution multi-echo fMRI in infants at 7T.

Approach: Acquire data in the same infant at 3T/7T within the same week, allowing for direct comparisons, while also considering unique safety guidelines for 7T infant imaging.

Results: Initial data demonstrate 3T/7T multi-echo fMRI in the same infant, establishing the feasibility of high-resolution ME-fMRI at 7T in infants with high contrast, sensitivity, and stronger functional connections.

Impact: This first demonstration of multi-echo fMRI at 7T, including the use of voxel volumes (1.6 mm³) that are half the volume of what is normally used in 3T infant fMRI (2.0 mm³), promises opportunities to advance developmental neuroimaging.

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